History shows that metal-based drugs and remedies have been known and used since very
ancient times. For example, silver was employed in the treatment of wounds and ulcers …

Significance: During the past decades, thiosemicarbazones were clinically developed for a
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …

Being a structural and catalytic cofactor in a number of biological pathways, copper
accumulates in tumors owing to selective permeability of the cancer cell membranes …

Thiosemicarbazones (TSCs) are a class of Schiff bases usually obtained by the
condensation of thiosemicarbazide with a suitable aldehyde or ketone. TSCs have been the …

Six morpholine-(iso) thiosemicarbazone hybrids HL 1–HL 6 and their Cu (II) complexes with
good-to-moderate solubility and stability in water were synthesized and characterized. Cu …

A series of water-soluble sodium salts of 3-formyl-4-hydroxybenzenesulfonic acid
thiosemicarbazones (or sodium 5-sulfonate-salicylaldehyde thiosemicarbazones) …

Recently, mixed-ligand copper (II) complexes have received much attention in searching for
alternative metallodrugs to cisplatin. A series of mixed ligand Cu (II) complexes of the type …

Over 44 million people live with Alzheimer's disease (AD) worldwide. Currently, only
symptomatic treatments are available for AD and no cure exists. Considering the lack of …

As ribonucleotide reductase (RNR) plays a crucial role in nucleic acid metabolism, it is an
important target for anticancer therapy. The thiosemicarbazone Triapine is an efficient R2 …

Chitosan is a polyfunctional biomaterial that is subjected to chemical modification through
functionalization to give the derivatives of remarkable anticancer activity. In this study …