Macrophages and tertiary lymphoid structures as indicators of prognosis and therapeutic response in cancer patients

L Niu, T Chen, A Yang, X Yan, F Jin, A Zheng… - Biochimica et Biophysica …, 2024 - Elsevier
Tertiary lymphoid structures (TLS) can reflect cancer prognosis and clinical outcomes in
various tumour tissues. Tumour-associated macrophages (TAMs) are indispensable …

Therapeutic Targeting of TIM-4-L With Engineered T Cells for Acute Myeloid Leukemia

B Cieniewicz, E Oliveira, M Saxton, D Torabi… - Clinical Cancer …, 2024 - AACR
Purpose: Disruption of lipid bilayer asymmetry is a common feature observed in cancer cells
and offers novel routes for therapeutic targeting. We used the natural immune receptor TIM-4 …

Intraperitoneal programming of tailored CAR macrophages via mRNA-LNP to boost cancer immunotherapy

K Gu, T Liang, L Hu, Y Zhao, W Ying, M Zhang, Y Chen… - bioRxiv, 2024 - biorxiv.org
Therapeutic strategies for peritoneal metastasis in solid tumors are urgently needed in the
clinic. Programming chimeric antigen receptor macrophages (CAR-Ms) in situ offers …