The protein corona and its effects on nanoparticle-based drug delivery systems
H Li, Y Wang, Q Tang, D Yin, C Tang, E He, L Zou… - Acta biomaterialia, 2021 - Elsevier
In most cases, once nanoparticles (NPs) enter the blood, their surface is covered by
biological molecules, especially proteins, forming a so-called protein corona (PC). As a …
biological molecules, especially proteins, forming a so-called protein corona (PC). As a …
Amphiphilic nature of polyethylene glycols and their role in medical research
Background Polyethylene glycol (PEG) is a polyether compound which is an excellent
candidate to study possible specific interactions of protein-polymer systems at the atomic …
candidate to study possible specific interactions of protein-polymer systems at the atomic …
Pre-molten, wet, and dry molten globules en route to the functional state of proteins
MN Gupta, VN Uversky - International Journal of Molecular Sciences, 2023 - mdpi.com
Transitions between the unfolded and native states of the ordered globular proteins are
accompanied by the accumulation of several intermediates, such as pre-molten globules …
accompanied by the accumulation of several intermediates, such as pre-molten globules …
[HTML][HTML] Seaweed polysaccharides as macromolecular crowding agents
Abstract Development of mesenchymal stem cell-based tissue engineered implantable
devices requires prolonged in vitro culture for the development of a three-dimensional …
devices requires prolonged in vitro culture for the development of a three-dimensional …
Interaction of polyethylene glycol with cytochrome c investigated via in vitro and in silico approaches
One of the significant proteins that have attracted research groups due to virtue of being a
potent selective anticancer drug target and property of triggering apoptosis upon release in …
potent selective anticancer drug target and property of triggering apoptosis upon release in …
Shape-dependent macromolecular crowding on the thermodynamics and microsecond conformational dynamics of protein unfolding revealed at the single-molecule …
One of the main differences in the intercellular environment compared to the laboratory
condition is the presence of macromolecular crowders of various compositions, sizes, and …
condition is the presence of macromolecular crowders of various compositions, sizes, and …
Heparin accelerates the protein aggregation via the downhill polymerization mechanism: multi-spectroscopic studies to delineate the implications on proteinopathies
Heparin is one of the members of the glycosaminoglycan (GAG) family, which has been
associated with protein aggregation diseases including Alzheimer's disease, Parkinson's …
associated with protein aggregation diseases including Alzheimer's disease, Parkinson's …
Rationalizing the role of monosodium glutamate in the protein aggregation through biophysical approaches: Potential impact on neurodegeneration
Monosodium glutamate (MSG) is the world's most extensively used food additive and is
generally recognized as safe according to the FDA. However, it is well reported that MSG is …
generally recognized as safe according to the FDA. However, it is well reported that MSG is …
Size-dependent macromolecular crowding effect on the thermodynamics of protein unfolding revealed at the single molecular level
The real biological environment involves a high degree of complexity and the
macromolecular crowder is the best candidate to somewhat mimic this. In this contribution …
macromolecular crowder is the best candidate to somewhat mimic this. In this contribution …
Size-Dependent Interplay of Volume Exclusion Versus Soft Interactions: Cytochrome c in Macromolecular Crowded Environment
Even though there are a great number of possible conformational states, how a protein
generated as a linear unfolded polypeptide efficiently folds into its physiologically active …
generated as a linear unfolded polypeptide efficiently folds into its physiologically active …