Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …

Organisms experience dramatic fluctuations in demands and stresses over the course of the
day. In order to maintain biological processes within physiological boundaries, mechanisms …

Mammalian circadian rhythms are controlled by endogenous biological oscillators, including
a master clock located in the hypothalamic suprachiasmatic nuclei (SCN). Since the period …

Time in the biological sense is measured by cycles that range from milliseconds to years.
Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most …

Life is a cyclical chemical process that is regulated in four dimensions. We distinguish parts
of the cycle: development describes the changes from single cell to adult, and aging the …

Mammalian circadian rhythms are regulated by the suprachiasmatic nucleus (SCN), and
current dogma holds that the SCN is required for the expression of circadian rhythms in …

In mammals, circadian oscillators exist not only in the suprachiasmatic nucleus, which
harbors the central pacemaker, but also in most peripheral tissues. It is believed that the …

Regulation of circadian period in humans was thought to differ from that of other species,
with the period of the activity rhythm reported to range from 13 to 65 hours (median 25.2 …

In mammals, circadian control of physiology and behavior is driven by a master pacemaker
located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene …

In multicellular organisms, circadian oscillators are organized into multitissue systems which
function as biological clocks that regulate the activities of the organism in relation to …