Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …

Plasmodium falciparum and Plasmodium vivax, the two protozoan parasite species that
cause the majority of cases of human malaria, have developed resistance to nearly all …

In Tanzania, chloroquine was replaced by sulphadoxine-pyrimethamine (SP) as a first-line
for treatment of uncomplicated malaria. Due to high resistance in malaria parasites, SP …

In regions with high malaria endemicity, the withdrawal of chloroquine (CQ) as first-line
treatment of Plasmodium falciparum infections has typically led to the restoration of CQ …

In the malaria parasite P. falciparum, drug resistance generally evolves first in low-
transmission settings, such as Southeast Asia and South America. Resistance takes …

Background Chloroquine, a previous highly efficacious, easy to use and affordable anti-
malarial agent was withdrawn from malaria endemic regions due to high levels of …

Abstract Background Increased resistance by Plasmodium falciparum parasites led to the
withdrawal of the antimalarial drugs chloroquine and sulphadoxine-pyrimethamine in …

In a climate of growing concern that Plasmodium falciparum may be developing a drug
resistance to artemisinin derivatives in the Guiana Shield, this review details our current …

Background Artemisinin and partner drug resistant malaria parasites have emerged in
Southeast Asia. If resistance were to emerge in Africa it could have a devastating impact on …

Antimalarial drug resistance has threatened global malaria control since chloroquine (CQ)-
resistant Plasmodium falciparum emerged in Asia in the 1950s. Understanding the impacts …