Biochemical and mechanical regulation of actin dynamics

P Lappalainen, T Kotila, A Jégou… - … Reviews Molecular Cell …, 2022 - nature.com
Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

Bringing structure to cell biology with cryo-electron tomography

LN Young, E Villa - Annual review of biophysics, 2023 - annualreviews.org
Recent advances in cryo-electron microscopy have marked only the beginning of the
potential of this technique. To bring structure into cell biology, the modality of cryo-electron …

[HTML][HTML] Capturing actin assemblies in cells using in situ cryo-electron tomography

J Schneider, M Jasnin - European Journal of Cell Biology, 2022 - Elsevier
Actin contributes to an exceptionally wide range of cellular processes through the assembly
and disassembly of highly dynamic and ordered structures. Visualizing these structures in …

[HTML][HTML] The mammalian endocytic cytoskeleton

A Abouelezz, L Almeida-Souza - European Journal of Cell Biology, 2022 - Elsevier
Clathrin-mediated endocytosis (CME) is the major route through which cells internalise
various substances and recycle membrane components. Via the coordinated action of many …

Mem3DG: modeling membrane mechanochemical dynamics in 3D using discrete differential geometry

C Zhu, CT Lee, P Rangamani - Biophysical reports, 2022 - cell.com
Biomembranes adopt varying morphologies that are vital to cellular functions. Many studies
use computational modeling to understand how various mechanochemical factors contribute …

Load adaptation by endocytic actin networks

C Kaplan, SJ Kenny, X Chen… - Molecular biology of …, 2022 - Am Soc Cell Biol
Clathrin-mediated endocytosis (CME) robustness under elevated membrane tension is
maintained by actin assembly–mediated force generation. However, whether more actin …

Analysis of functional surfaces on the actin nucleation promoting factor Dip1 required for Arp2/3 complex activation and endocytic actin network assembly

SL Liu, HY Narvaez-Ortiz, M Miner, J Kiemel… - Journal of Biological …, 2022 - ASBMB
Arp2/3 complex nucleates branched actin filaments that drive processes like endocytosis
and lamellipodial protrusion. WISH/DIP/SPIN90 (WDS) proteins form a class of Arp2/3 …

Adaptive actin organization buffers endocytosis against changes in membrane tension

C Kaplan, SJ Kenny, S Chen, J Schöneberg, E Sitarska… - BioRxiv, 2020 - biorxiv.org
Clathrin-mediated endocytosis (CME) remains robust despite variation in plasma membrane
tension. Actin assembly-mediated force generation becomes essential for CME under high …

[PDF][PDF] Mem3DG: Modeling Membrane Mechanochemical Dynamics in 3D using

C Zhu, CT Lee, P Rangamani - scholar.archive.org
Biomembranes adopt varying morphological configurations that are vital to cellular
functions. Many studies 8 use computational modeling to understand how various …