The intracellular interactions of biomolecules can be maneuvered to redirect signaling,
reprogram the cell cycle, or decrease infectivity using only a few dozen atoms. Such …

Marine actinobacteria are one of the most efficient groups of secondary metabolite
producers and are very important from an industrial point of view. Many representatives of …

Fungi or bacteria that produce secondary metabolites often have the potential to bring up
various compounds from a single strain. The molecular basis for this well‐known …

Chemotherapy is one of the main treatments used to combat cancer. A great number of
antitumor compounds are natural products or their derivatives, mainly produced by …

Molecular glues are an intriguing therapeutic modality that harness small molecules to
induce interactions between proteins that typically do not interact. However, such molecules …

Cyclopropane, epoxide, and aziridine groups are three-membered ring structural elements
found in a wide variety of natural products, some of which are depicted in Figure 1. 1 The …

Small molecule inhibitors that target components of the spliceosome have great potential as
tools to probe splicing mechanism and dissect splicing regulatory networks in cells. These …

Covering: up to early 2001The biosynthesis and mode of attachment of a wide range of
polyketide synthase (PKS) starter units in bacteria are covered in this review. Natural …

The frequent natural occurrence of cyclohexane epoxides, coupled with the wide range of
interesting biological activities that they display, has made these compounds of …

Cancer is the leading cause of deaths worldwide, though significant advances have
occurred in its diagnosis and treatment. The development of resistance against …