Molecular glue discovery: current and future approaches
JA Dewey, C Delalande, SA Azizi, V Lu… - Journal of medicinal …, 2023 - ACS Publications
The intracellular interactions of biomolecules can be maneuvered to redirect signaling,
reprogram the cell cycle, or decrease infectivity using only a few dozen atoms. Such …
reprogram the cell cycle, or decrease infectivity using only a few dozen atoms. Such …
[HTML][HTML] Pharmaceutically active secondary metabolites of marine actinobacteria
P Manivasagan, J Venkatesan, K Sivakumar… - Microbiological …, 2014 - Elsevier
Marine actinobacteria are one of the most efficient groups of secondary metabolite
producers and are very important from an industrial point of view. Many representatives of …
producers and are very important from an industrial point of view. Many representatives of …
Big effects from small changes: possible ways to explore nature's chemical diversity
HB Bode, B Bethe, R Höfs, A Zeeck - ChemBioChem, 2002 - Wiley Online Library
Fungi or bacteria that produce secondary metabolites often have the potential to bring up
various compounds from a single strain. The molecular basis for this well‐known …
various compounds from a single strain. The molecular basis for this well‐known …
[HTML][HTML] Antitumor compounds from marine actinomycetes
Chemotherapy is one of the main treatments used to combat cancer. A great number of
antitumor compounds are natural products or their derivatives, mainly produced by …
antitumor compounds are natural products or their derivatives, mainly produced by …
Manumycin polyketides act as molecular glues between UBR7 and P53
Y Isobe, M Okumura, LM McGregor, SM Brittain… - Nature chemical …, 2020 - nature.com
Molecular glues are an intriguing therapeutic modality that harness small molecules to
induce interactions between proteins that typically do not interact. However, such molecules …
induce interactions between proteins that typically do not interact. However, such molecules …
Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis
Cyclopropane, epoxide, and aziridine groups are three-membered ring structural elements
found in a wide variety of natural products, some of which are depicted in Figure 1. 1 The …
found in a wide variety of natural products, some of which are depicted in Figure 1. 1 The …
Modulating splicing with small molecular inhibitors of the spliceosome
KA Effenberger, VK Urabe… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Small molecule inhibitors that target components of the spliceosome have great potential as
tools to probe splicing mechanism and dissect splicing regulatory networks in cells. These …
tools to probe splicing mechanism and dissect splicing regulatory networks in cells. These …
Biosynthesis and attachment of novel bacterial polyketide synthase starter units
BS Moore, C Hertweck - Natural product reports, 2002 - pubs.rsc.org
Covering: up to early 2001The biosynthesis and mode of attachment of a wide range of
polyketide synthase (PKS) starter units in bacteria are covered in this review. Natural …
polyketide synthase (PKS) starter units in bacteria are covered in this review. Natural …
Naturally occurring cyclohexane epoxides: sources, biological activities, and synthesis
J Marco-Contelles, MT Molina, S Anjum - Chemical reviews, 2004 - ACS Publications
The frequent natural occurrence of cyclohexane epoxides, coupled with the wide range of
interesting biological activities that they display, has made these compounds of …
interesting biological activities that they display, has made these compounds of …
Bacteria and bacterial anticancer agents as a promising alternative for cancer therapeutics
P Baindara, SM Mandal - Biochimie, 2020 - Elsevier
Cancer is the leading cause of deaths worldwide, though significant advances have
occurred in its diagnosis and treatment. The development of resistance against …
occurred in its diagnosis and treatment. The development of resistance against …