Cardiac hypertrophy, initiated by a variety of physiological or pathological stimuli
(hemodynamic or hormonal stimulation or infarction), is a critical early adaptive …

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation is a
promising therapy for Alzheimer's disease (AD). However, hUC-MSCs cultured in vitro easily …

Abstract Background and Objective Our previous studies demonstrated that MG53 protein
can protect the myocardium, but its use as a therapeutic is challenging due to its short half …

Aims Heart failure (HF) is a prevalent age‐related cardiovascular disease with poor
prognosis in the elderly population. This study aimed to establish the causal relationship …

Oxidative stress plays a crucial role in cadmium (Cd)-induced myocardial injury. Mitsugumin
53 (MG53) and its mediated reperfusion injury salvage kinase (RISK) pathway have been …

Chronic muscle inflammation exacerbates the pathogenesis of Duchenne muscular
dystrophy (DMD), which is characterized by progressive muscle degeneration and …

Kidney fibrosis is associated with the progression of acute kidney injury to chronic kidney
disease. MG53, a cell membrane repair protein, has been shown to protect against injury to …

Doxorubicin (DOX) is an anthracycline medication that is commonly used to treat solid
tumors. However, DOX has limited clinical efficacy due to known cardiotoxicity. Ferroptosis is …

Progressive age-induced deterioration in the structure and function of the cardiovascular
system involves cardiac hypertrophy, diastolic dysfunction, myocardial fibrosis, arterial …

Aims Subjects with type 2 diabetes (T2D) are characterized by a high cardiovascular
morbidity and mortality. MG53, a marker of peripheral insulin resistance, has been linked …