Over the last two decades, we have witnessed a revolution in the field of Parkinson's
disease (PD) genetics. Great advances have been made in identifying many loci that confer …

Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central
nervous system, ranging from the regulation of gene transcription, cellular signaling …

We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty …

Microglia are long-living resident immune cells of the brain, which secure a stable chemical
and physical microenvironment necessary for the proper functioning of the central nervous …

Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …

Chronic inflammation is a major characteristic feature of Parkinson's disease (PD). Studies
in PD patients show evidence of augmented levels of potent pro-inflammatory molecules eg …

Heterozygous, loss-of-function mutations in the granulin gene (GRN) encoding progranulin
(PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN …

Mitochondrial dysfunction has been implicated in the etiology of monogenic Parkinson's
disease (PD). Yet the role that mitochondrial processes play in the most common form of the …

Parkinson's disease is caused by a complex interplay of genetic and environmental factors.
Although a number of independent molecular pathways and processes have been …

Parkinson's disease (PD) is a complex multi-factorial neurodegenerative disorder where
various altered metabolic pathways contribute to the progression of the disease. Tryptophan …