[HTML][HTML] Dopamine and addiction
RA Wise, MA Robble - Annual review of psychology, 2020 - annualreviews.org
Addiction is commonly identified with habitual nonmedical self-administration of drugs. It is
usually defined by characteristics of intoxication or by characteristics of withdrawal …
usually defined by characteristics of intoxication or by characteristics of withdrawal …
How does adenosine control neuronal dysfunction and neurodegeneration?
RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
JD Salamone, SE Yohn, L López-Cruz, N San Miguel… - Brain, 2016 - academic.oup.com
Motivation has been defined as the process that allows organisms to regulate their internal
and external environment, and control the probability, proximity and availability of stimuli. As …
and external environment, and control the probability, proximity and availability of stimuli. As …
G protein–coupled receptor oligomerization revisited: functional and pharmacological perspectives
Most evidence indicates that, as for family CG protein–coupled receptors (GPCRs), family A
GPCRs form homo-and heteromers. Homodimers seem to be a predominant species, with …
GPCRs form homo-and heteromers. Homodimers seem to be a predominant species, with …
New insights into modes of GPCR activation
W Wang, Y Qiao, Z Li - Trends in pharmacological sciences, 2018 - cell.com
In classical G-protein-coupled receptor (GPCR) activation, GPCRs couple to a variety of
heterotrimeric G proteins on the membrane and then activate downstream signaling …
heterotrimeric G proteins on the membrane and then activate downstream signaling …
[HTML][HTML] Adenosine receptors and brain diseases: neuroprotection and neurodegeneration
Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …
Mesolimbic dopamine and the regulation of motivated behavior
It has been known for some time that nucleus accumbens dopamine (DA) is involved in
aspects of motivation, but theoretical approaches to understanding the functions of DA have …
aspects of motivation, but theoretical approaches to understanding the functions of DA have …
Allostery at G protein-coupled receptor homo-and heteromers: uncharted pharmacological landscapes
NJ Smith, G Milligan - Pharmacological reviews, 2010 - ASPET
For many years seven transmembrane domain G protein-coupled receptors (GPCRs) were
thought to exist and function exclusively as monomeric units. However, evidence both from …
thought to exist and function exclusively as monomeric units. However, evidence both from …
Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher‐order oligomers in living cells
N Cabello, J Gandía, DCG Bertarelli… - Journal of …, 2009 - Wiley Online Library
G protein‐coupled receptors are known to form homo‐and heteromers at the plasma
membrane, but the stoichiometry of these receptor oligomers are relatively unknown. Here …
membrane, but the stoichiometry of these receptor oligomers are relatively unknown. Here …
Persistent cognitive dysfunction after traumatic brain injury: a dopamine hypothesis
Traumatic brain injury (TBI) represents a significant cause of death and disability in
industrialized countries. Of particular importance to patients the chronic effect that TBI has on …
industrialized countries. Of particular importance to patients the chronic effect that TBI has on …