Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

Hippo pathway components are structurally and functionally conserved and are notable for
their role in controlling organ size. More diverse functions of the Hippo pathway have been …

The ocular lens is a model system for understanding important aspects of embryonic
development, such as cell specification and the spatiotemporally controlled formation of a …

Abstract The Hippo/Yap pathway is a well-conserved signaling cascade that regulates cell
proliferation and differentiation to control organ size and stem/progenitor cell behavior …

Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …

Hippo/YAP signaling plays pleiotropic roles in the regulation of cell proliferation and
differentiation during organogenesis and tissue repair. Herein we demonstrate increased …

This chapter provides an overview of the early developmental origins of six ocular tissues:
the cornea, lens, ciliary body, iris, neural retina, and retina pigment epithelium. Many of …

Timely generation and normal maturation of ependymal cells along the aqueduct are critical
for preventing physical blockage between the third and fourth ventricles and the …

Yap functions as a transcriptional regulator by acting together with sequence-specific DNA
binding factors and transcription cofactors to mediate cell proliferation in developing …

Background Promoters and enhancers are cis-regulatory DNA sequences that control
specificity and quantity of transcription. Both are rich on clusters of cis-acting sites that …