Abstract The epithelial Na+ channel (ENaC) and the acid-sensing ion channels (ASICs) form
subfamilies within the ENaC/degenerin family of Na+ channels. ENaC mediates …

Acid-sensing ion channels (ASICs) are ligand-gated ion channels that are exquisitely
sensitive to extracellular protons and can sense transient as well as sustained acidification …

Acid-sensing ion channels are proton-activated, sodium-selective channels composed of
three subunits, and are members of the superfamily of epithelial sodium channels …

Acid-sensing ion channels (ASICs) are voltage-independent, amiloride-sensitive channels
involved in diverse physiological processes ranging from nociception to taste. Despite the …

Acid-sensing ion channels (ASICs) are Na+-permeable ion channels activated by protons
and predominantly expressed in the nervous system. ASICs act as pH sensors leading to …

Acid-sensing ion channels (ASICs) are H+-gated Na+ channels, which are present in most, if
not all, neurons. The typical ASIC current is transient and is elicited by a rapid drop in the …

Acid-sensing ion channels (ASICs) respond to acidosis that normally occurs after
inflammation. We examined the expression of ASIC1, ASIC2, and ASIC3 mRNAs in lumbar …

Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin
(ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes …

Ion channel targeted drugs have always been related with either the central nervous system
(CNS), the peripheral nervous system, or the cardiovascular system. Within the CNS, basic …

Acid-sensing ion channels (ASICs) are widely expressed proton-gated Na+ channels
playing a role in tissue acidosis and pain. A trimeric composition of ASICs has been …