Since their discovery, fluorescent probes have found widespread use in biological research.
Over time, multiple next-generation probes increased the fluorescence catalog by offering …

Pain is a complex multidimensional experience encompassing sensory-discriminative,
affective-motivational and cognitive-emotional components mediated by different neural …

Throughout the past decade the use of fluorogen activating proteins (FAPs) has expanded
with several unique reporter dyes that support a variety of methods to specifically quantify …

BK calcium-activated potassium channels have complex kinetics because they are activated
by both voltage and cytoplasmic calcium. The timing of BK activation and deactivation during …

Neuropeptides control rhythmic behaviors, but the timing and location of their release within
circuits is unknown. Here, imaging in the brain shows that synaptic neuropeptide release by …

The limited success of plaque-reducing therapies in Alzheimer's disease suggests that early
treatment might be more effective in delaying or reversing memory impairments. Toward this …

Despite 50+ years of clinical use as anxiolytics, anti-convulsants, and sedative/hypnotic
agents, the mechanisms underlying benzodiazepine (BZD) tolerance are poorly understood …

Anatomical methods for determining cell type-specific connectivity are essential to inspire
and constrain our understanding of neural circuit function. We developed genetically …

BK Ca2+-activated K+ channels are important regulators of membrane excitability. Multiple
regulatory mechanisms tailor BK current properties across tissues, such as alternative …

LRRC55 (leucine-rich repeat-containing protein 55) protein is an auxiliary γ subunit of BK
(Big conductance potassium channel) channels, which leftward shifts GVs of BK channels …