Quinoline drug–heme interactions and implications for antimalarial cytostatic versus cytocidal activities
Historically, the most successful molecular target for antimalarial drugs has been heme
biomineralization within the malarial parasite digestive vacuole. Heme released from …
biomineralization within the malarial parasite digestive vacuole. Heme released from …
[HTML][HTML] Drug targets for resistant malaria: historic to future perspectives
New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …
Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine
KN Olafson, MA Ketchum, JD Rimer… - Proceedings of the …, 2015 - National Acad Sciences
Hematin crystallization is the primary mechanism of heme detoxification in malaria parasites
and the target of the quinoline class of antimalarials. Despite numerous studies of malaria …
and the target of the quinoline class of antimalarials. Despite numerous studies of malaria …
Evaluation of the anti-malarial activity of crude extract and solvent fractions of the leaves of Olea europaea (Oleaceae) in mice
D Misganaw, E Engidawork, T Nedi - BMC Complementary and …, 2019 - Springer
Background Drug resistance poses a challenge to malaria control measures. This calls for
discovery & development of new chemotherapeutic agents. This study therefore was …
discovery & development of new chemotherapeutic agents. This study therefore was …
Immunological and biochemical interplay between cytokines, oxidative stress and schistosomiasis
The host–parasite schistosome relationship relies heavily on the interplay between the
strategies imposed by the schistosome worm and the defense mechanisms the host uses to …
strategies imposed by the schistosome worm and the defense mechanisms the host uses to …
RNA Interference in Schistosoma mansoni Schistosomula: Selectivity, Sensitivity and Operation for Larger-Scale Screening
Background The possible emergence of resistance to the only available drug for
schistosomiasis spurs drug discovery that has been recently incentivized by the availability …
schistosomiasis spurs drug discovery that has been recently incentivized by the availability …
Natural products as leads in schistosome drug discovery
Schistosomiasis is a neglected parasitic tropical disease that claims around 200,000 human
lives every year. Praziquantel (PZQ), the only drug recommended by the World Health …
lives every year. Praziquantel (PZQ), the only drug recommended by the World Health …
Heme and blood-feeding parasites: friends or foes?
Hemoparasites, like malaria and schistosomes, are constantly faced with the challenges of
storing and detoxifying large quantities of heme, released from their catabolism of host …
storing and detoxifying large quantities of heme, released from their catabolism of host …
Antimalarial activity of hydromethanolic extract and its solvent fractions of Vernonia amygdalina leaves in mice infected with Plasmodium berghei
Background: Vernonia amygdalina Del.(Asteraceae) is reported to be traditionally used for
the treatment of malaria. Based on folkloric repute of this plant in Ethiopian traditional …
the treatment of malaria. Based on folkloric repute of this plant in Ethiopian traditional …
Orally active antischistosomal early leads identified from the open access malaria box
K Ingram-Sieber, N Cowan, G Panic… - PLoS neglected …, 2014 - journals.plos.org
Background Worldwide hundreds of millions of schistosomiasis patients rely on treatment
with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel …
with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel …