Organ-on-a-Chip (OOC) technology, which emulates the physiological environment and
functionality of human organs on a microfluidic chip, is undergoing significant technological …

Hyperthermic nanomedicines are particularly relevant for tackling human cancer, providing
a valuable alternative to conventional therapeutics. The early-stage preclinical performance …

One of the hurdles to the development of new anticancer therapies is the lack of in vitro
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …

Microphysiological system or organ-on-a-chip technologies can replicate the key structure
and function of 3D human tissues with higher reproducibility than less controllable 3D cell …

The vasculature plays a critical role in cancer progression and metastasis, representing a
pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on …

Tumor spheroids as well as multicellular tumor spheroids (MCTSs) are promising 3D in vitro
tumor models for drug screening, drug design, drug targeting, drug toxicity, and validation of …

Background With the burgeoning advancements in disease modeling, drug development,
and precision medicine, organ-on-a-chip has risen to the forefront of biomedical research …

Colorectal cancer (CRC) is a leading cause of death worldwide. Improved preclinical tumor
models are needed to make treatment screening clinically relevant and address disease …

Tumor metastasis involves complex processes that traditional 2D cultures and animal
models struggle to fully replicate. Metastatic tumors undergo a multitude of transformations …

This study presents the vascularized tissue on mesh-assisted platform (VT-MAP), a novel
microfluidic in vitro model that uses an open microfluidic principle for cultivating vascularized …