Understanding neuroimmune interactions in disorders of gut–brain interaction: from functional to immune-mediated disorders

T Vanuytsel, P Bercik, G Boeckxstaens - Gut, 2023 - gut.bmj.com
Functional gastrointestinal disorders—recently renamed into disorders of gut–brain
interaction—such as irritable bowel syndrome and functional dyspepsia are highly prevalent …

Melatonin in food allergy: Mechanism and potential therapy

H Wang, Y Yan, I Hung, C Liu, J Yin… - Journal of Pineal …, 2023 - Wiley Online Library
Food allergy affects more than 500 million people in the world, and its prevalence is
increasing at an alarming rate causing serious public health concerns; however, prevention …

Immune tolerance of food is mediated by layers of CD4+ T cell dysfunction

SW Hong, PD Krueger, KC Osum, T Dileepan… - Nature, 2022 - nature.com
Gastrointestinal health depends on the adaptive immune system tolerating the foreign
proteins in food,. This tolerance is paradoxical because the immune system normally attacks …

Critical features of an in vitro intestinal absorption model to study the first key aspects underlying food allergen sensitization

W Dijk, C Villa, S Benedé… - … Reviews in Food …, 2023 - Wiley Online Library
New types of protein sources will enter our diet in a near future, reinforcing the need for a
straightforward in vitro (cell‐based) screening model to test and predict the safety of these …

Allergenicity of wheat protein in diet: Mechanisms, modifications and challenges

M Liu, J Huang, S Ma, G Yu, A Liao, L Pan… - Food research …, 2023 - Elsevier
Wheat is widely available in people's daily diets. However, some people are currently
experiencing IgE-mediated allergic reactions to wheat-based foods, which seriously impact …

The potential of orally exposed risk factors and constituents aggravating food allergy: Possible mechanism and target cells

X Xu, J Yuan, M Zhu, J Gao, X Meng… - … Reviews in Food …, 2024 - Wiley Online Library
Food allergy is a significant concern for the health of humans worldwide. In addition to
dietary exposure of food allergens, genetic and environmental factors also play an important …

Intestinal uptake and tolerance to food antigens

Y Xiong, G Xu, M Chen, H Ma - Frontiers in Immunology, 2022 - frontiersin.org
Food allergy is a growing concern due to its increasing world-wide incidence. Strict
avoidance of allergens is a passive treatment strategy. Since the mechanisms responsible …

The Immunobiology and Treatment of Food Allergy

S Barshow, J Tirumalasetty, V Sampath… - Annual Review of …, 2024 - annualreviews.org
IgE-mediated food allergy (IgE-FA) occurs due to a breakdown in immune tolerance that
leads to a detrimental type 2 helper T cell (TH2) adaptive immune response. While the …

Oral versus gastrointestinal mucosal immune niches in homeostasis and allostasis

LJ Suárez, S Arboleda, N Angelov… - Frontiers in Immunology, 2021 - frontiersin.org
Different body systems (epidermis, respiratory tract, cornea, oral cavity, and gastrointestinal
tract) are in continuous direct contact with innocuous and/or potentially harmful external …

Eosinophil Granule Proteins Involvement in Acute Appendicitis—An Allergic Disease?

N Carvalho, E Carolino, H Coelho, AL Barreira… - International Journal of …, 2023 - mdpi.com
Several pieces of evidence point to an allergic component as a trigger of acute appendicitis.
As the Th2 immune response is characterized by eosinophil mobilization to the target organ …