The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Segregation of the replicated genome during cell division in eukaryotes requires the
kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed …

Abstract N6-Methyladenosine (m6A) messenger RNA methylation is a well-known
epitranscriptional regulatory mechanism affecting central biological processes, but its …

The centromere is responsible for accurate chromosome segregation. Mammalian
centromeres are specified epigenetically, with all active centromeres containing centromere …

The basic element for chromosome inheritance, the centromere, is epigenetically
determined in mammals. The prime candidate for specifying centromere identity is the array …

Mitosis and meiosis are remarkable processes during which cells undergo profound
changes in their structure and physiology. These events are orchestrated with a precision …

The nucleus is one of the most prominent cellular organelles, yet surprisingly little is known
about how it is formed, what determines its shape and what defines its size. As the nuclear …

Centromeres direct chromosomal inheritance by nucleating assembly of the kinetochore, a
large multiprotein complex required for microtubule attachment during mitosis. Centromere …

Centromeres contain specialized nucleosomes in which histone H3 is replaced by the
histone variant centromere protein A (CENP-A). CENP-A nucleosomes are thought to act as …

In vertebrates, centromeres lack defined sequences and are thought to be propagated by
epigenetic mechanisms involving the incorporation of specialized nucleosomes containing …