Epidemiological studies point to race as a determining factor in cancer susceptibility. In US
registries recording cancer incidence and survival by race (distinguishing 'black versus …

Traumatic brain injury (TBI) is a major cause of death and disability in the United States,
exacting a debilitating physical, social, and financial strain. Therefore, it is crucial to examine …

Background Blacks tend to have a stronger inflammatory immune response than Whites. We
hypothesized that racial differences in host immunity also manifest in the tumor …

Importance Racial disparities in breast cancer (BC) survival arise from multilevel causes,
which may exert influence at different stages of BC progression. Clarifying the importance of …

The precision medicine concept and the unique disease principle imply that each patient
has unique pathogenic processes resulting from heterogeneous cellular genetic and …

Abstract Background African American/Black women with breast cancer have poorer
survival than White women, and this disparity persists even after adjusting for non-biological …

Abstract Human IL12RB1 encodes IL12Rβ1, a type I transmembrane receptor that is an
essential component of the IL12-and IL23-signaling complex. IL12RB1 is well-established …

Purpose Breast cancer is a heterogeneous disease, with at least five intrinsic subtypes
defined by molecular characteristics. Tumors that express the estrogen receptor (ER+) have …

Selection pressure due to exposure to infectious pathogens endemic to Africa may explain
distinct genetic variations in immune response genes. However, the impact of those genetic …

Individuals of African descent are disproportionately affected by specific complex diseases,
such as breast and prostate cancer, which are driven by both biological and nonbiological …