Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange. They are
exceptionally large protein complexes that fuse the inner and outer nuclear membranes to …

Cell division in eukaryotes requires extensive architectural changes of the nuclear envelope
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …

The nuclear envelope (NE) is a highly regulated membrane barrier that separates the
nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different …

Abstract The small nuclear GTPase Ran controls the directionality of macromolecular
transport between the nucleus and the cytoplasm. Ran also has important roles during …

Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope,
thereby connecting the nuclear interior with the cytoplasm. Until recently, these …

Nuclear pore complexes (NPCs) are composed of several copies of∼ 30 different proteins
called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the …

Nuclear pores span the nuclear envelope and act as gated aqueous channels to regulate
the transport of macromolecules between the nucleus and cytoplasm, from individual …

During mitosis in higher eukaryotes, nuclear pore complexes (NPCs) disassemble in
prophase and are rebuilt in anaphase and telophase. NPC formation is hypothesized to …

Repo-Man targets protein phosphatase 1 γ (PP1γ) to chromatin at anaphase onset and
regulates chromosome structure during mitotic exit. Here, we show that a Repo-Man: PP1 …

The unexpected repurposing of nuclear transport proteins from their function in interphase to
an equally vital and very different set of functions in mitosis was very surprising. The multi …