Background Recent advances in genomewide studies have revealed the abundance of long
non-coding RNAs (lncRNAs) in mammalian transcriptomes. The ENCODE Consortium has …

Long noncoding RNAs (lncRNAs) are a relatively poorly understood class of RNAs with little
or no coding capacity transcribed from a set of incompletely annotated genes. They have …

Xist represents a paradigm for the function of long non-coding RNA in epigenetic regulation,
although how it mediates X-chromosome inactivation (XCI) remains largely unexplained …

The availability of nutrients influences cellular growth and survival by affecting gene
transcription. Glucocorticoids also influence gene transcription and have diverse activities …

Long non-coding RNAs (lncRNAs) are a large and diverse group of RNAs that are often
lineage-specific and that regulate multiple biological functions. Many are nuclear and are …

While functional roles of several long non-coding RNAs (lncRNAs) have been determined,
the molecular mechanisms are not well understood. Here, we report the first experimentally …

So far, the characteristics of a good quality egg have been elusive, similar to the nature of
the physiological, cellular, and molecular cues leading to its production both in vivo and in …

Mutations in LRPPRC are responsible for the French Canadian variant of Leigh syndrome
(LSFC), a neurodegenerative disorder caused by a tissue-specific deficiency in cytochrome …

Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene
regulation. Studies conducted over a decade ago revealed that maturation of spliced …

MyoD regulates skeletal myogenesis. Since proteins associated with MyoD exert regulatory
functions, their identification is expected to contribute important insights into the mechanisms …