ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

Introduction Interindividual differences in drug response are a frequent clinical challenge
partly due to variation in pharmacokinetics. ATP-binding cassette (ABC) transporters are …

Inter‐ethnic variability in pharmacokinetics (PK) has been attributed to several factors
ranging from genetic to environmental. It is not clear how current teaching in higher …

The most accessible points of call for most African populations with respect to primary health
care are traditional health systems that include spiritual, religious, and herbal medicine. This …

Introduction: Efavirenz commonly causes early neuropsychiatric side effects, but tolerance
develops in most patients. There is emerging evidence that efavirenz use may damage …

Background HIV infection, anti-tuberculosis and efavirenz therapy are associated with
neuropsychological effects. We evaluated the influence of rifampicin cotreatment, efavirenz …

Aims Genetic factors, notably CYP2B6 516G→ T [rs3745274] and 983T→ C [rs28399499],
explain much of the interindividual variability in efavirenz pharmacokinetics, but data from …

Background Pharmacogenetics contributes to inter-individual variability in pharmacokinetics
(PK) of efavirenz (EFV), leading to variations in both efficacy and toxicity. The purpose of this …

Efavirenz is part of the first-line treatment for HIV patients including those in South Africa with
approximately 50% experiencing neuropsychiatric side effects. A systematic review of …

Introduction: Africa harbors a disproportionate burden of disease when taking into account
the triple challenge caused by HIV/AIDS, tuberculosis (TB) and malaria, against a backdrop …