Deoxyribonucleic acid (DNA) is a fundamental biomolecule for correct cellular functioning
and regulation of biological processes. DNA's structure is dynamic and has the ability to …

RNAi has always captivated scientists due to its tremendous power to modulate the
phenotype of living organisms. This natural and powerful biological mechanism can now be …

RNA uptake by cells is critical for RNA-mediated gene interference (RNAi) and RNA-based
therapeutics. In Caenorhabditis elegans, RNAi is systemic as a result of SID-1-mediated …

One of the major challenges of nanomedicine and gene therapy is the effective translocation
of drugs and genes across cell membranes. In this study, we describe a systematic …

Recently, nucleic acid drugs have been considered as promising candidates in treatment of
various diseases, especially cancer. Because of developing resistance to conventional …

Various structural, dynamic and thermodynamic properties of water molecules confined in
single-wall carbon nanotubes (CNTs) are investigated using both polarizable and non …

Cost-effective, fast, and reliable DNA sequencing can be enabled by advances in nanopore-
based methods, such as the use of atomically thin graphene membranes. However, strong …

Pore functionalization has been explored by several groups as a strategy to control DNA
translocation through solid-state nanopores. Here we present a hybrid nanopore system …

We report a structural polymorphism of the S-DNA when a canonical B-DNA is stretched
under different pulling protocols and provide a fundamental molecular understanding of the …

Using atomistic molecular dynamics simulations, we report graphene-assisted spontaneous
unzipping of a novel duplex ribonucleic acid analogue xylonucleic acid (XNA) at …