Pathophysiology and genetics of salt-sensitive hypertension
Most hypertensive cases are primary and heavily associated with modifiable risk factors like
salt intake. Evidence suggests that even small reductions in salt consumption reduce blood …
salt intake. Evidence suggests that even small reductions in salt consumption reduce blood …
Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery
S Gao, X Liu, T Li, L Chen, Y Feng, Y Wang… - Acta Pharmacologica …, 2024 - nature.com
Heart failure (HF) with preserved ejection fraction (HFpEF) is currently a preeminent
challenge for cardiovascular medicine. It has a poor prognosis, increasing mortality, and is …
challenge for cardiovascular medicine. It has a poor prognosis, increasing mortality, and is …
Chronic treatment with IL-25 increases renal M2 macrophages and reduces renal injury in obese Dahl salt-sensitive rats during the prepubescent stage
Recently, we have reported that the early progression of proteinuria in the obese Dahl salt-
sensitive (SS) leptin receptor mutant (SSLepRmutant) strain was associated with increased …
sensitive (SS) leptin receptor mutant (SSLepRmutant) strain was associated with increased …
Placental ischemia-stimulated T-helper 17 cells induce preeclampsia-associated cytolytic natural killer cells during pregnancy
CA Shields, M McCalmon, T Ibrahim… - American Journal …, 2018 - journals.physiology.org
Previous studies have demonstrated that T-helper 17 (TH17) cells and cytolytic natural killer
(cNK) cells are increased in women with preeclampsia. In this study we investigated the role …
(cNK) cells are increased in women with preeclampsia. In this study we investigated the role …
IL-33 supplementation improves uterine artery resistance and maternal hypertension in response to placental ischemia
X Wang, C Shields, G Tardo… - American Journal …, 2024 - journals.physiology.org
Preeclampsia (PE), a leading cause of maternal/fetal morbidity and mortality, is a
hypertensive pregnancy disorder with end-organ damage that manifests after 20 wk of …
hypertensive pregnancy disorder with end-organ damage that manifests after 20 wk of …
NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia
X Wang, OK Travis, CA Shields… - American Journal …, 2023 - journals.physiology.org
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder with end-organ damage
that presents after 20 wk of gestation. PE pathophysiology often includes vascular …
that presents after 20 wk of gestation. PE pathophysiology often includes vascular …
Treatment with lisinopril prevents the early progression of glomerular injury in obese Dahl salt-sensitive rats independent of lowering arterial pressure
AK Brown, A Nichols, CA Coley, US Ekperikpe… - Frontiers in …, 2021 - frontiersin.org
Recently, we reported that obese Dahl salt-sensitive leptin receptor mutant (SSLepRmutant)
rats develop glomerular injury and progressive proteinuria prior to puberty. Moreover, this …
rats develop glomerular injury and progressive proteinuria prior to puberty. Moreover, this …
Neutralizing MIP3α Reduces Renal Immune Cell Infiltration and Progressive Renal Injury in Young Obese Dahl Salt-Sensitive Rats
Recently, we reported that the early progression of renal injury in obese Dahl salt-sensitive
leptin receptor mutant (SSLepRmutant) rats was associated with increased macrophage …
leptin receptor mutant (SSLepRmutant) rats was associated with increased macrophage …
IL‐33 Signaling Inhibition Leads to a Preeclampsia‐Like Phenotype in Pregnant Rats
X Wang, CA Shields, D Thompson… - American Journal of …, 2024 - Wiley Online Library
Problem Preeclampsia (PE) is a hypertensive pregnancy disorder that is a leading cause of
maternal and fetal morbidity and mortality characterized by maternal vascular dysfunction …
maternal and fetal morbidity and mortality characterized by maternal vascular dysfunction …
Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats
US Ekperikpe, S Mandal, SJ Holt… - American Journal …, 2023 - journals.physiology.org
Prepubertal obesity is currently an epidemic and is considered as a major risk factor for
renal injury. Previous studies have demonstrated that insulin resistance contributes to renal …
renal injury. Previous studies have demonstrated that insulin resistance contributes to renal …