Pathophysiology and genetics of salt-sensitive hypertension

D Maaliki, MM Itani, HA Itani - Frontiers in Physiology, 2022 - frontiersin.org
Most hypertensive cases are primary and heavily associated with modifiable risk factors like
salt intake. Evidence suggests that even small reductions in salt consumption reduce blood …

Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery

S Gao, X Liu, T Li, L Chen, Y Feng, Y Wang… - Acta Pharmacologica …, 2024 - nature.com
Heart failure (HF) with preserved ejection fraction (HFpEF) is currently a preeminent
challenge for cardiovascular medicine. It has a poor prognosis, increasing mortality, and is …

Chronic treatment with IL-25 increases renal M2 macrophages and reduces renal injury in obese Dahl salt-sensitive rats during the prepubescent stage

B Poudel, US Ekperikpe, S Mandal… - American Journal …, 2023 - journals.physiology.org
Recently, we have reported that the early progression of proteinuria in the obese Dahl salt-
sensitive (SS) leptin receptor mutant (SSLepRmutant) strain was associated with increased …

Placental ischemia-stimulated T-helper 17 cells induce preeclampsia-associated cytolytic natural killer cells during pregnancy

CA Shields, M McCalmon, T Ibrahim… - American Journal …, 2018 - journals.physiology.org
Previous studies have demonstrated that T-helper 17 (TH17) cells and cytolytic natural killer
(cNK) cells are increased in women with preeclampsia. In this study we investigated the role …

IL-33 supplementation improves uterine artery resistance and maternal hypertension in response to placental ischemia

X Wang, C Shields, G Tardo… - American Journal …, 2024 - journals.physiology.org
Preeclampsia (PE), a leading cause of maternal/fetal morbidity and mortality, is a
hypertensive pregnancy disorder with end-organ damage that manifests after 20 wk of …

NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia

X Wang, OK Travis, CA Shields… - American Journal …, 2023 - journals.physiology.org
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder with end-organ damage
that presents after 20 wk of gestation. PE pathophysiology often includes vascular …

Treatment with lisinopril prevents the early progression of glomerular injury in obese Dahl salt-sensitive rats independent of lowering arterial pressure

AK Brown, A Nichols, CA Coley, US Ekperikpe… - Frontiers in …, 2021 - frontiersin.org
Recently, we reported that obese Dahl salt-sensitive leptin receptor mutant (SSLepRmutant)
rats develop glomerular injury and progressive proteinuria prior to puberty. Moreover, this …

Neutralizing MIP3α Reduces Renal Immune Cell Infiltration and Progressive Renal Injury in Young Obese Dahl Salt-Sensitive Rats

US Ekperikpe, B Poudel, CA Shields, S Mandal… - … of Pharmacology and …, 2023 - ASPET
Recently, we reported that the early progression of renal injury in obese Dahl salt-sensitive
leptin receptor mutant (SSLepRmutant) rats was associated with increased macrophage …

IL‐33 Signaling Inhibition Leads to a Preeclampsia‐Like Phenotype in Pregnant Rats

X Wang, CA Shields, D Thompson… - American Journal of …, 2024 - Wiley Online Library
Problem Preeclampsia (PE) is a hypertensive pregnancy disorder that is a leading cause of
maternal and fetal morbidity and mortality characterized by maternal vascular dysfunction …

Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats

US Ekperikpe, S Mandal, SJ Holt… - American Journal …, 2023 - journals.physiology.org
Prepubertal obesity is currently an epidemic and is considered as a major risk factor for
renal injury. Previous studies have demonstrated that insulin resistance contributes to renal …