Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein
DP Noone, MME Isendoorn, SMWR Hamers… - Proceedings of the …, 2024 - pnas.org
Human C-reactive protein (CRP) is a pentameric complex involved in immune defense and
regulation of autoimmunity. CRP is also a therapeutic target, with both administration and …
regulation of autoimmunity. CRP is also a therapeutic target, with both administration and …
[HTML][HTML] Enhancing complement activation by therapeutic anti-tumor antibodies: Mechanisms, strategies, and engineering approaches
V Ovcinnikovs, K Dijkman, GG Zom, FJ Beurskens… - Seminars in …, 2025 - Elsevier
The complement system plays an integral role in both innate and adaptive immune
responses. Beyond its protective function against infections, complement is also known to …
responses. Beyond its protective function against infections, complement is also known to …
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation
The development of agonists capable of activating the human complement system by
binding to the C1 complex presents a novel approach for targeted cell killing. Bispecific …
binding to the C1 complex presents a novel approach for targeted cell killing. Bispecific …
Antibody density on bacteria regulates C1q recruitment by monoclonal IgG but not IgM
N Aymerich, LJ Schlotheuber… - European Journal of …, 2024 - Wiley Online Library
Antibodies that trigger the complement system play a pivotal role in the immune defense
against pathogenic bacteria and offer potential therapeutic avenues for combating antibiotic …
against pathogenic bacteria and offer potential therapeutic avenues for combating antibiotic …