A review of current methods in microfluidic device fabrication and future commercialization prospects

BK Gale, AR Jafek, CJ Lambert, BL Goenner… - Inventions, 2018 - mdpi.com
Microfluidic devices currently play an important role in many biological, chemical, and
engineering applications, and there are many ways to fabricate the necessary channel and …

Microfluidic organs-on-chips

SN Bhatia, DE Ingber - Nature biotechnology, 2014 - nature.com
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …

25th anniversary article: Rational design and applications of hydrogels in regenerative medicine

N Annabi, A Tamayol, JA Uquillas, M Akbari… - Advanced …, 2014 - Wiley Online Library
Hydrogels are hydrophilic polymer‐based materials with high water content and physical
characteristics that resemble the native extracellular matrix. Because of their remarkable …

Organ‐on‐a‐chip platforms: a convergence of advanced materials, cells, and microscale technologies

S Ahadian, R Civitarese, D Bannerman… - Advanced …, 2018 - Wiley Online Library
Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

From 3D cell culture to organs-on-chips

D Huh, GA Hamilton, DE Ingber - Trends in cell biology, 2011 - cell.com
3D cell-culture models have recently garnered great attention because they often promote
levels of cell differentiation and tissue organization not possible in conventional 2D culture …

On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves

X Ding, SCS Lin, B Kiraly, H Yue, S Li… - Proceedings of the …, 2012 - National Acad Sciences
Techniques that can dexterously manipulate single particles, cells, and organisms are
invaluable for many applications in biology, chemistry, engineering, and physics. Here, we …

Engineers are from PDMS-land, Biologists are from Polystyrenia

E Berthier, EWK Young, D Beebe - Lab on a Chip, 2012 - pubs.rsc.org
As the integration of microfluidics into cell biology research proceeds at an ever-increasing
pace, a critical question for those working at the interface of both disciplines is which device …

Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications

D Mark, S Haeberle, G Roth, F Von Stetten… - Microfluidics based …, 2010 - Springer
This review summarizes recent developments in microfluidic platform approaches. In
contrast to isolated application-specific solutions, a microfluidic platform provides a set of …

Microfluidics: Fluid physics at the nanoliter scale

TM Squires, SR Quake - Reviews of modern physics, 2005 - APS
Microfabricated integrated circuits revolutionized computation by vastly reducing the space,
labor, and time required for calculations. Microfluidic systems hold similar promise for the …

Engineering flows in small devices: microfluidics toward a lab-on-a-chip

HA Stone, AD Stroock, A Ajdari - Annu. Rev. Fluid Mech., 2004 - annualreviews.org
Microfluidic devices for manipulating fluids are widespread and finding uses in many
scientific and industrial contexts. Their design often requires unusual geometries and the …