DFT, molecular docking, molecular dynamics simulation, MMGBSA calculation and hirshfeld surface analysis of 5-sulfosalicylic acid

A Fatima, H Arora, P Bhattacharya, N Siddiqui… - Journal of Molecular …, 2023 - Elsevier
Experimental studies were conducted on 5-Sulfosalicylic Acid (5-SSA) using NMR (1Hsingle
bondNMR and 13 Csingle bondNMR), FT-IR, UV–Visible, and quantum chemical methods …

Structure-based virtual screening, molecular docking, and molecular dynamics simulation of VEGF inhibitors for the clinical treatment of ovarian cancer

S Mukherjee, M Abdalla, M Yadav, M Madhavi… - Journal of Molecular …, 2022 - Springer
Vascular endothelial growth factor (VEGF) and its receptor play an important role both in
physiologic and pathologic angiogenesis, which is identified in ovarian cancer progression …

Potential inhibitors designed against NDM-1 type metallo-β-lactamases: an attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria

AU Khan, A Ali, Danishuddin, G Srivastava… - Scientific reports, 2017 - nature.com
NDM-1 and its variants are the most prevalent types of metallo-β-lactamases, hydrolyze
almost all antibiotics of β-lactam group leading to multiple-drug resistance in bacteria. No …

Structure-based virtual screening, molecular docking, molecular dynamics simulation and pharmacokinetic modelling of cyclooxygenase-2 (COX-2) inhibitor for the …

M Yadav, M Abdalla, M Madhavi, I Chopra… - Molecular …, 2022 - Taylor & Francis
Colorectal cancer is the third most frequent cause of cancer worldwide and is more
prevalent in older individuals of all ages. The recent statistics from World Health …

Repurposing drug molecule against SARS-Cov-2 (COVID-19) through molecular docking and dynamics: a quick approach to pick FDA-approved drugs

N Farhat, AU Khan - Journal of Molecular Modeling, 2021 - Springer
A novel coronavirus known as severe acute respiratory syndrome is rapidly spreading
worldwide. The international health authorities are putting all their efforts on quick diagnosis …

Molecular and computational approaches to understand resistance of New Delhi metallo β-lactamase variants (NDM-1, NDM-4, NDM-5, NDM-6, NDM-7)-producing …

A Ali, D Gupta, G Srivastava, A Sharma… - Journal of Biomolecular …, 2019 - Taylor & Francis
The discovery of NDM-1 and its variants has caused the emergence of antibiotic resistance
in the community and hospital setting, causing major concern for health care across the …

Molecular investigation of active binding site of isoniazid (INH) and insight into resistance mechanism of S315T-MtKatG in Mycobacterium tuberculosis

G Srivastava, S Tripathi, A Kumar, A Sharma - Tuberculosis, 2017 - Elsevier
Multi drug resistant tuberculosis is a major threat for mankind. Resistance against Isoniazid
(INH), targeting MtKatG protein, is one of the most commonly occurring resistances in MDR …

Density functional studies and spectroscopic analysis (FT-IR, FT-Raman, UV–visible, and NMR) with molecular docking approach on an anticancer and antifungal …

G Khanum, A Kumar, M Singh, A Fatima… - Journal of Molecular …, 2022 - Elsevier
hydroxy-3-methoxybenzaldehyde was investigated quantum chemically by DFT approach,
surface analysis by Hirshfeld and experimentally by NMR (FT-IR, UV-Visible 1Hsingle …

Synthesis, crystal structure, hirshfeld surface analysis, molecular docking and molecular dynamics studies of novel olanzapinium 2, 5-dihydroxybenzoate as potential …

V Natchimuthu, M Abdalla, M Yadav… - Journal of …, 2022 - Taylor & Francis
The antipsychotic drug Olanzapine was crystallized with aromatic acid, 2, 5-
dihydroxybenzoic acid in isopropyl alcohol by slow evaporation which led to the formation of …

[PDF][PDF] Inhibition of Viral Macrodomain of COVID-19 and Human TRPM2 by losartan

AS Jazzi, K Mahnam, SH Hejazi, MS Damavandi… - Preprint, 2020 - researchgate.net
Abstract Background: The SARS-CoV-2 virus is a new highly contagious Coronavirus with a
positivesense RNA encoding 16 non-structural proteins (nsps16, nsp15, nsp3). In this study …