The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …

Ischemia and reperfusion (I/R) causes a reduction in arterial blood supply to tissues,
followed by the restoration of perfusion and consequent reoxygenation. The reestablishment …

Abstract Background Interleukin-1 beta (IL-1β) and its key regulator, the inflammasome, are
suspected to play a role in the neuroinflammation observed in Alzheimer's disease (AD); no …

Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently,
compelling evidence has arisen for the role of monocytes and neutrophils and a particular …

Highlights•Host-derived molecules (eg β-amyloid, tau) trigger NLRP3 inflammasome
signaling.•TNF, ATP, serum amyloid A and the microbiome regulate NLRP3 inflammasome …

The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-
containing 3) inflammasome mediates production of inflammatory mediators, such as IL-1β …

The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein
complex that activates caspase 1, leading to the processing and secretion of the pro …

Stress is a common occurrence in everyday life and repeated or traumatic stress can be a
precipitating factor for illnesses of the central nervous system, as well as peripheral organ …

The inflammatory microenvironment has been shown to play important roles in various
stages of tumor development including initiation, growth, and metastasis. The inflammasome …

Interleukin-1β (IL-1β), reactive oxygen species (ROS), and thioredoxin-interacting protein
(TXNIP) are all implicated in the pathogenesis of type 2 diabetes mellitus (T2DM). Here we …