COVID-19 and diabetes: understanding the interrelationship and risks for a severe course

CP Landstra, EJP de Koning - Frontiers in endocrinology, 2021 - frontiersin.org
The relationship between COVID-19 and diabetes mellitus is complicated and bidirectional.
On the one hand, diabetes mellitus is considered one of the most important risk factors for a …

[HTML][HTML] Diabetes, infection risk and COVID-19

S Erener - Molecular metabolism, 2020 - Elsevier
Background Individuals with diabetes are at a greater risk of hospitalization and mortality
resulting from viral, bacterial, and fungal infections. The coronavirus disease-2019 (COVID …

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

SL Wong, M Demers, K Martinod, M Gallant, Y Wang… - Nature medicine, 2015 - nature.com
Wound healing is impaired in diabetes, resulting in significant morbidity and mortality.
Neutrophils are the main leukocytes involved in the early phase of healing. As part of their …

Fracture healing under healthy and inflammatory conditions

L Claes, S Recknagel, A Ignatius - Nature Reviews Rheumatology, 2012 - nature.com
Optimal fracture treatment requires knowledge of the complex physiological process of bone
healing. The course of bone healing is mainly influenced by fracture fixation stability …

New insights into neutrophil extracellular traps: mechanisms of formation and role in inflammation

H Yang, MH Biermann, JM Brauner, Y Liu… - Frontiers in …, 2016 - frontiersin.org
Recent data suggest that NETosis plays a crucial role in the innate immune response and
disturbs the homeostasis of the immune system. NETosis is a form of neutrophil-specific cell …

IL-1β implications in type 1 diabetes mellitus progression: systematic review and meta-analysis

F Cano-Cano, L Gómez-Jaramillo… - Journal of clinical …, 2022 - mdpi.com
During Type 1 Diabetes Mellitus (T1DM) progression, there is chronic and low-grade
inflammation that could be related to the evolution of the disease. We carried out a …

Obesity and insulin resistance: associations with chronic inflammation, genetic and epigenetic factors

A Gasmi, S Noor, A Menzel, L Pivina… - Current medicinal …, 2021 - ingentaconnect.com
Background: Obesity is known to be a multifactorial disease. In its pathogenesis, different
factors such as chronic inflammation, oxidative stress, insulin resistance, genetic factors …

[HTML][HTML] Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging

SL Wong, DD Wagner - The FASEB Journal, 2018 - ncbi.nlm.nih.gov
Abstract Peptidylarginine deiminase 4 (PAD4) is a nuclear citrullinating enzyme that is
critically involved in the release of decondensed chromatin from neutrophils as neutrophil …

[HTML][HTML] Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8

S Toosi, SJ Orlow, P Manga - Journal of investigative dermatology, 2012 - Elsevier
Vitiligo is characterized by depigmented skin patches caused by loss of epidermal
melanocytes. Oxidative stress may have a role in vitiligo onset, while autoimmunity …

Low-grade inflammation in type 2 diabetes: a cross-sectional study from a Danish diabetes outpatient clinic

T Okdahl, AM Wegeberg, F Pociot, B Brock, J Størling… - BMJ open, 2022 - bmjopen.bmj.com
Objectives To investigate low-grade inflammation in type 2 diabetes and explore
associations to clinical aspects as well as microvascular and macrovascular complications …