[HTML][HTML] Clinically approved combination immunotherapy: Current status, limitations, and future perspective

L Lu, M Zhan, XY Li, H Zhang, DJ Dauphars… - Current research in …, 2022 - Elsevier
Immune-checkpoint inhibitor-based combination immunotherapy has become a first-line
treatment for several major types of cancer including hepatocellular carcinoma (HCC), renal …

Understanding sorafenib-induced ferroptosis and resistance mechanisms: implications for cancer therapy

Q Li, K Chen, T Zhang, D Jiang, L Chen, J Jiang… - European Journal of …, 2023 - Elsevier
Sorafenib is an important first-line treatment option for liver cancer due to its well-
characterized safety profile. While novel first-line drugs may have better efficacy than …

[HTML][HTML] Immunotherapy or targeted therapy as the first-line strategies for unresectable hepatocellular carcinoma: a network meta-analysis and cost-effectiveness …

K Liu, Y Zhu, H Zhu - Frontiers in Immunology, 2023 - frontiersin.org
Introduction The existence of many phase III randomized controlled trials (RCTs) of first-line
treatment for unresectable hepatocellular carcinoma (HCC) puzzle doctors and patients in …

Atezolizumab plus bevacizumab versus nivolumab as first‐line treatment for advanced or unresectable hepatocellular carcinoma: A cost‐effectiveness analysis

Y Li, X Liang, H Li, X Chen - Cancer, 2022 - Wiley Online Library
Background The cost effectiveness of atezolizumab plus bevacizumab (atezo‐beva) versus
nivolumab treatment for advanced or unresectable hepatocellular carcinoma is still …

Multidisciplinary Treatment of Hepatocellular Carcinoma in 2023: Italian practice Treatment Guidelines of the Italian Association for the Study of the Liver (AISF), Italian …

G Cabibbo, B Daniele, M Borzio… - Digestive and Liver …, 2024 - Elsevier
Worldwide, hepatocellular carcinoma (HCC) is the third most common cause of cancer-
related death. The remarkable improvements in treating HCC achieved in the last years …

An overview: management of patients with advanced hepatocellular carcinoma

J Wang, R Wu, J Sun, F Lei, H Tan, X Lu - BioScience Trends, 2022 - jstage.jst.go.jp
Hepatocellular carcinoma (HCC) has constituted a significant health burden worldwide, and
patients with advanced HCC, which is stage C as defined by the Barcelona Clinic Liver …

[HTML][HTML] Sintilimab plus bevacizumab biosimilar versus sorafenib as first-line treatment for unresectable hepatocellular carcinoma: A cost-effectiveness analysis

Y Peng, X Zeng, L Peng, Q Liu, L Yi, X Luo… - Frontiers in …, 2022 - frontiersin.org
Objective: The ORIENT-32 clinical trial revealed that sintilimab plus bevacizumab biosimilar
significantly improved the median progression-free survival and median overall survival …

[HTML][HTML] New challenges facing systemic therapies of advanced HCC in the era of different first-line immunotherapy-based combinations

J Edeline, T Meyer, JF Blanc, JL Raoul - Cancers, 2022 - mdpi.com
Simple Summary In this review, we detail the data on a new treatment of hepatocellular
carcinoma. A new combination of therapies, based on immunotherapy, has recently …

First-line treatments for advanced hepatocellular carcinoma: a network meta-analysis and cost-effectiveness analysis in China and the United States

KX Sun, SS Cao, FH Shi, Y Guan… - Therapeutic …, 2022 - journals.sagepub.com
Background: Various therapeutic strategies are available for the first-line treatment of
patients with advanced hepatocellular carcinoma (aHCC). But which approach is the most …

Updated efficacy and safety data from IMbrave150: atezolizumab plus bevacizumab vs. Sorafenib for unresectable hepatocellular carcinoma

A Roy - Journal of Clinical and Experimental Hepatology, 2022 - jcehepatology.com
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and remains a
significant cause of cancerrelated death globally. The incidence of HCC has been on the …