DNA repair pathways are triggered to maintain genetic stability and integrity when
mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The …

The prognosis of advanced mesothelioma is poor. Podoplanin (PDPN) is highly expressed
in most malignant mesothelioma. This study aimed to evaluate the potential alpha …

Apurinic/apyrimidinic (AP) sites appear in DNA spontaneously and as intermediates of base
excision DNA repair. AP sites are noninstructive lesions: they strongly block DNA …

Non-small cell lung cancer (NSCLC) is a major form of cancer and is resistant to chemo-and
radio-therapy. Vicenin-2 (VCN-2) is a flavonoid obtained from Ocimum sanctum L. and it has …

Podoplanin is a type I transmembrane sialomucin‐like glycoprotein that is highly expressed
in malignant mesothelioma. The rat‐human chimeric antibody NZ‐12 has high affinity for …

Drug-loaded magnetic nanoparticles have been developed because of the advantages of
specific drug targeting in cancer treatment. Pemetrexed (PEM) is a multi-targeting antifolate …

Abstract Purpose: TRC102, a small-molecule base-excision repair inhibitor, potentiates the
cytotoxicity of pemetrexed and reverses resistance by binding to chemotherapy-induced …

Folic-acid-based radioconjugates have been developed for nuclear imaging of folate
receptor (FR)-positive tumors; however, high renal uptake was unfavorable in view of a …

Lung adenocarcinoma (LUAD) has high morbidity and mortality worldwide, and its
prognosis remains unsatisfactory. Identification of epigenetic biomarkers associated with …

Adenosquamous carcinoma (ASC) is a rare histological type of intrahepatic
cholangiocarcinoma, which includes both adenocarcinoma and squamous cell carcinoma …