The many roles of dystroglycan in nervous system development and function: Dystroglycan and neural circuit development

JN Jahncke, KM Wright - Developmental Dynamics, 2023 - Wiley Online Library
The glycoprotein dystroglycan was first identified in muscle, where it functions as part of the
dystrophin glycoprotein complex to connect the extracellular matrix to the actin cytoskeleton …

High degree of conservation of the enzymes synthesizing the laminin-binding glycoepitope of α-dystroglycan

MG Bigotti, A Brancaccio - Open biology, 2021 - royalsocietypublishing.org
The dystroglycan (DG) complex plays a pivotal role for the stabilization of muscles in
Metazoa. It is formed by two subunits, extracellular α-DG and transmembrane β-DG …

Loss of swiss cheese in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets …

PA Melentev, EV Ryabova, NV Surina… - International journal of …, 2021 - mdpi.com
Various neurodegenerative disorders are associated with human NTE/PNPLA6 dysfunction.
Mechanisms of neuropathogenesis in these diseases are far from clearly elucidated …

Basement membrane diversification relies on two competitive secretory routes defined by Rab10 and Rab8 and modulated by dystrophin and the exocyst complex

C Dennis, P Pouchin, G Richard, V Mirouse - PLoS genetics, 2024 - journals.plos.org
The basement membrane (BM) is an essential structural element of tissues, and its
diversification participates in organ morphogenesis. However, the traffic routes associated …

Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier

MI Tsap, AS Yatsenko, J Hegermann, B Beckmann… - Elife, 2024 - elifesciences.org
Abstract Mutations in Drosophila Swiss cheese (SWS) gene or its vertebrate orthologue
neuropathy target esterase (NTE) lead to progressive neuronal degeneration in flies and …

Signaling through the dystrophin glycoprotein complex affects the stress-dependent transcriptome in Drosophila

TD Carney, RY Hebalkar, E Edeleva… - Disease Models & …, 2023 - journals.biologists.com
Deficiencies in the human dystrophin glycoprotein complex (DGC), which links the
extracellular matrix with the intracellular cytoskeleton, cause muscular dystrophies, a group …

[HTML][HTML] Review Commons Transfer: Signaling through the dystrophin glycoprotein complex affects the stress-dependent transcriptome in Drosophila

TD Carney, RY Hebalkar, E Edeleva… - Disease Models & …, 2023 - ncbi.nlm.nih.gov
Deficiencies in the human dystrophin glycoprotein complex (DGC), which links the
extracellular matrix with the intracellular cytoskeleton, cause muscular dystrophies, a group …

The polyadenosine RNA binding protein Nab2 regulates alternative splicing and intron retention during Drosophila melanogaster brain development

S Kelly, A Paschack, G Mishra, E Smith, K Shelmidine… - bioRxiv, 2024 - biorxiv.org
The regulation of cell-specific gene expression patterns during development requires the
coordinated actions of hundreds of proteins, including transcription factors, processing …

[PDF][PDF] A FUNCTIONAL ROLE FOR DYSTROGLYCAN AT INHIBITORY SYNAPSES ACROSS MULTIPLE BRAIN REGIONS

JN Jahncke - 2024 - scholar.archive.org
A FUNCTIONAL ROLE FOR DYSTROGLYCAN AT INHIBITORY SYNAPSES ACROSS
MULTIPLE BRAIN REGIONS By Jennifer N. Jahncke A DISSERTATION Pr Page 1 A …