Previous meta-analyses of structural MRI studies have shown diffuse cortical and sub-
cortical abnormalities in unipolar depression. However, the presence of duplicate …

Corticotropin-releasing hormone (CRH) plays a central role in the regulation of the
hypothalamic-pituitary-adrenal (HPA)-axis, ie, the final common pathway in the stress …

Context Although differences in clinical characteristics exist between major depressive
disorder (MDD) and bipolar disorder (BD), consistent structural brain abnormalities that …

Context Despite 25 years of structural imaging in bipolar disorder, brain regions affected in
the disorder are ill defined. Objectives To use meta-analytical techniques to investigate …

BackgroundSeveral magnetic resonance imaging (MRI) studies have identified structural
abnormalities in association with bipolar disorder. The literature is, however, heterogeneous …

Objective: Despite effective pharmacological treatments for bipolar disorder, we still lack a
comprehensive pathophysiological model of the illness. Recent neurobiological research …

There is growing evidence from neuroimaging and ostmortem studies that severe mood
disorders, which have traditionally been conceptualized as neurochemical disorders, are …

The role of dysfunctional endocrine systems in the pathogenesis of mood disorders has
been the focus of research for many decades. The complexity of endocrine systems and …

Background: As patients with mood disorders manifest heterogeneity in phenomenology,
pathophysiology, etiology, and treatment response, a biological classification of mental …

Suicidal behavior and mood disorders are one of the world's largest public health problems.
The biological vulnerability for these problems includes genetic factors involved in the …