Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …

Infection and inflammation induce the acutephase response (APR), leading to multiple
alterations in lipid and lipoprotein metabolism. Plasma triglyceride levels increase from …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

Inflammation associates with peripheral insulin resistance, which dysregulates nutrient
homeostasis and leads to diabetes. Inflammation induces the expression of SOCS proteins …

Adipocytes are the defining cell type of adipose tissue. Once considered a passive
participant in energy storage, adipose tissue is now recognized as a dynamic organ that …

Resistin is a recently discovered polypeptide that induces insulin resistance in rodents.
While in rodents resistin is predominantly expressed in adipocytes, in humans peripheral …

Skeletal muscle constitutes the largest insulin‐sensitive tissue in the body and is the primary
site for insulin‐stimulated glucose utilization. Skeletal muscle resistance to insulin is …

The biology of peroxisome proliferator activated receptors (PPARs) in physiological and
pathophysiological processes has been primarily studied in peripherial organs and tissues …

Adipocytes play important roles in lipid storage, energy homeostasis and whole body insulin
sensitivity. The JAK–STAT (Janus Kinase–Signal Transducer and Activator of Transcription) …

Rationale: Stimulation of the NLRP3 inflammasome by metabolic byproducts is known to
result in inflammatory responses and metabolic diseases. However, how the host controls …