Reactive oxygen species‐(ROS‐) induced lipid peroxidation plays a critical role in cell death
including apoptosis, autophagy, and ferroptosis. This fundamental and conserved …

In ferroptosis, the roles of mitochondria have been controversial. To explore the role of
mitochondrial events in ferroptosis, we employed mitochondrial DNA-depleted ρ0 cells that …

Mitochondria are dynamic organelles, which serve various purposes, including but not
limited to the production of ATP and various metabolites, buffering ions, acting as a signaling …

Acetaminophen (APAP) overdose is a common cause of drug-induced liver injury (DILI).
Ferroptosis has been recently implicated in APAP-induced liver injury (AILI). However, the …

Rationale: Ferroptosis, a newly identified form of regulated cell death, can be induced
following the inhibition of cystine-glutamate antiporter system X C-because of the impaired …

Abstract Prokineticin-2 (Prok2) is an important secreted protein likely involved in the
pathogenesis of several acute and chronic neurological diseases through currently …

Trastuzumab (TRZ) is a first-line chemotherapeutic agent for HER-2 (ErbB2)-positive breast
cancer. Unfortunately, its clinical use is limited due to its cardiotoxicity, referred to as TRZ …

Ferroptosis is a necrotic form of cell death caused by inactivation of the glutathione system
and uncontrolled iron-mediated lipid peroxidation. Increasing evidence implicates …

Mitochondrial DNA (mtDNA) released through protein oligomers, such as voltage-
dependent anion channel 1 (VDAC1), triggers innate immune activation and thus …

Epidemiological studies have established an association between chronic exposure to PM
2.5 and male infertility. However, the underlying mechanisms were not fully revealed. In this …