Alzheimer's disease (AD) is the most common form of neurodegenerative disorder with
dementia, accounting for approximately 70% of the all cases. Currently, 5.8 million people in …

Nucleation of new peptide and protein aggregates on the surfaces of amyloid fibrils of the
same peptide or protein has emerged in the past two decades as a major pathway for both …

Secondary nucleation of monomers on the surface of an already existing aggregate that is
formed from the same kind of monomers may lead to autocatalytic amplification of a self …

Background Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese
encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents …

Inhibition of amyloid β peptide (Aβ) aggregation is an important goal due to the connection
of this process with Alzheimer's disease. Traditionally, inhibitors were developed with an aim …

The formation of amyloid deposits in human tissues is a defining feature of more than 50
medical disorders, including Alzheimer's disease. Strong genetic and histological evidence …

Environmental toxicants have been implicated in neurodegenerative diseases, and
pesticide exposure is a suspected environmental risk factor for Alzheimer's disease (AD) …

Abstract Glycogen synthase kinase‐3 (GSK3), consisting of GSK3α and GSK3β subtypes, is
a complex protein kinase that regulates numerous substrates. Research has observed …

Background Alzheimer's disease (AD)-linked β-amyloid (Aβ) accumulates in multivesicular
bodies (MVBs) with the onset of AD pathogenesis. Alterations in endosomes are among the …

The aggregation of the amyloid β peptide (Aβ) into amyloid fibrils is a defining characteristic
of Alzheimer's disease. Because of the complexity of this aggregation process, effective …