Prostate cancer is the most frequently diagnosed malignancy in American men, and a more
aggressive form of the disease is particularly prevalent among African Americans. The …

Context Active surveillance (AS) is an important strategy to reduce prostate cancer
overtreatment. However, the optimal criteria for eligibility and predictors of progression while …

Background: Standard clinical parameters cannot accurately differentiate indolent from
aggressive prostate cancer. Our previous work showed that immunohistochemical (IHC) Ki …

Context Active surveillance (AS) is an alternative to initial radical treatment of low-risk
prostate cancer (PCa). Current criteria for selection and follow-up incorrectly exclude some …

The combined clinical and molecular heterogeneity of prostate cancer necessitates the use
of prognostic, predictive, and diagnostic biomarkers to assist the clinician with treatment …

Context The incidence of low-risk prostate cancer (PCa) has increased as a consequence of
prostate-specific antigen testing. Objective In this collaborative review article, we examine …

Accurate prognostic parameters in prostate biopsies are needed to better counsel individual
patients with prostate cancer. We evaluated the prognostic impact of morphologic and …

Localized prostate cancer (PCa) is a clinically heterogeneous disease, which presents with
variability in patient outcomes within the same risk stratification (low, intermediate or high) …

Background It is a commonly accepted belief that cancer cells modify their transcriptional
state during the progression of the disease. We propose that the progression of cancer cells …

Objective. The aim of this study was to explore whether vascular density and tumour cell
proliferation are related to the risk of prostate cancer death in patients managed by watchful …