Cellular mechanisms of melatonin: insight from neurodegenerative diseases
D Chen, T Zhang, TH Lee - Biomolecules, 2020 - mdpi.com
Neurodegenerative diseases are the second most common cause of death and
characterized by progressive impairments in movement or mental functioning in the central …
characterized by progressive impairments in movement or mental functioning in the central …
Phosphorylation signaling in APP processing in Alzheimer's disease
T Zhang, D Chen, TH Lee - International journal of molecular sciences, 2019 - mdpi.com
The abnormal accumulation of amyloid-β (Aβ) in the central nervous system is a hallmark of
Alzheimer's disease (AD). The regulation of the processing of the single-transmembrane …
Alzheimer's disease (AD). The regulation of the processing of the single-transmembrane …
Kinases control of regulated cell death revealing druggable targets for Parkinson's disease
HM Mansour, AF Mohamed, AS El-Khatib… - Ageing Research …, 2023 - Elsevier
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in the
world. Motor impairment seen in PD is associated with dopaminergic neurotoxicity in the …
world. Motor impairment seen in PD is associated with dopaminergic neurotoxicity in the …
Chemotherapy resistance: Role of mitochondrial and autophagic components
E Bahar, SY Han, JY Kim, H Yoon - Cancers, 2022 - mdpi.com
Simple Summary Chemotherapy resistance is a common occurrence during cancer
treatment that cancer researchers are attempting to understand and overcome. Mitochondria …
treatment that cancer researchers are attempting to understand and overcome. Mitochondria …
Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Parkinson's disease
Parkinson's disease (PD) is a debilitating neurological disorder characterized by the
impairment of the motor system, resulting in symptoms such as resting tremor, cogwheel …
impairment of the motor system, resulting in symptoms such as resting tremor, cogwheel …
A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets
Aptamer-based proteomics revealed differentially abundant proteins in Alzheimer's disease
(AD) brains in the Baltimore Longitudinal Study of Aging and Religious Orders Study (mean …
(AD) brains in the Baltimore Longitudinal Study of Aging and Religious Orders Study (mean …
Potential implications of miRNAs in the pathogenesis, diagnosis, and therapeutics of Alzheimer's disease
L Wang, X Shui, Y Diao, D Chen, Y Zhou… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a complex multifactorial disorder that poses a substantial
burden on patients, caregivers, and society. Considering the increased aging population …
burden on patients, caregivers, and society. Considering the increased aging population …
miR-143-3p inhibits aberrant tau phosphorylation and amyloidogenic processing of APP by directly targeting DAPK1 in Alzheimer's disease
L Wang, X Shui, Y Mei, Y Xia, G Lan, L Hu… - International Journal of …, 2022 - mdpi.com
The neuropathology of Alzheimer's disease (AD) is characterized by intracellular
aggregation of hyperphosphorylated tau and extracellular accumulation of beta-amyloid …
aggregation of hyperphosphorylated tau and extracellular accumulation of beta-amyloid …
[HTML][HTML] Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease
T Zhang, Y Xia, L Hu, D Chen, CL Gan… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
The aggregation of amyloid-β (Aβ) peptides into oligomers and fibrils is a key pathological
feature of Alzheimer's disease (AD). An increasing amount of evidence suggests that …
feature of Alzheimer's disease (AD). An increasing amount of evidence suggests that …
Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer's Disease
L Wang, Y Zhou, D Chen, TH Lee - Frontiers in cell and …, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of dementia with cognitive decline. The
neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles …
neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles …