Tauopathies are classified according to whether tau deposits predominantly contain tau
isoforms with three or four repeats of the microtubule-binding domain. Those in which four …

Neurodegenerative diseases are characterised by selective dysfunction and progressive
loss of synapses and neurons associated with pathologically altered proteins that deposit …

There is poor knowledge about the clinical effects of Lewy body (LB) pathology in patients
with cognitive impairment, especially when coexisting with Alzheimer's disease (AD) …

Corticobasal degeneration (CBD) is a neurodegenerative tauopathy—a class of disorders in
which the tau protein forms insoluble inclusions in the brain—that is characterized by motor …

Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical
pathology in neurons, astrocytes, and oligodendroglia associated with various clinical …

Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including
cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread …

Background Progressive supranuclear palsy is a neurodegenerative disorder associated
with tau protein aggregation. Tilavonemab (ABBV-8E12) is a monoclonal antibody that binds …

Importance Progressive supranuclear palsy (PSP) is a 4-repeat tauopathy. Region-specific
tau aggregates establish the neuropathologic diagnosis of definite PSP post mortem. Future …

Recent mechanistic and structural studies have challenged the classical tauopathy
classification approach and revealed the complexity and heterogeneity of tau pathology in …

Aggregation and deposition of β-amyloid and/or tau protein are the key neuropathological
features in neurodegenerative disorders such as Alzheimer's disease (AD) and other …