Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …

Understanding the pathogenesis and clinical manifestations of systemic lupus
erythematosus (SLE) has been a great challenge. Reductionist approaches to understand …

CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular
signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed …

Infection caused by SARS-CoV-2 can result in severe respiratory complications and death.
Patients with a compromised immune system are expected to be more susceptible to a …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
immune tolerance and sustained production of autoantibodies. Multiple and profound T cell …

Daratumumab, a human monoclonal antibody that targets CD38, depletes plasma cells and
is approved for the treatment of multiple myeloma. Long-lived plasma cells are implicated in …

As the world navigates the coronavirus disease 2019 (COVID-19) pandemic, there is a
growing need to assess its impact in patients with autoimmune rheumatic diseases, such as …

The majority of patients with systemic lupus erythematosus (SLE) have high expression of
type I IFN-stimulated genes. Mitochondrial abnormalities have also been reported, but the …

Infection is one of the major causes of mortality in patients with systemic lupus
erythematosus (SLE). We previously found that CD38, an ectoenzyme that regulates the …