Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …

Glycosylation of proteins is an essential process in all eukaryotes and a great diversity in
types of protein glycosylation exists in animals, plants and microorganisms. Mucin-type O …

Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …

BACKGROUND: Posttranslational modifications (PTMs) greatly expand the function and
regulation of proteins, and glycosylation is the most abundant and diverse PTM. Of the many …

Glycosaminoglycans (GAGs) are complex polysaccharides, which play important roles in
cell growth, differentiation, morphogenesis, cell migration, and bacterial/viral infections …

Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and variously implicated in …

Several cholangiopathies result from a perturbation of developmental processes. Most of
these cholangiopathies are characterised by the persistence of biliary structures with foetal …

The biliary tract consists of a network of intrahepatic and extrahepatic ducts that collect and
drain the bile produced by hepatocytes to the gut. The bile ducts are lined by …

Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) are covalently
attached to specific core proteins to form proteoglycans in their biosynthetic pathways. They …

The primary cilium protrudes like an antenna from the cell surface, sensing mechanical and
chemical cues provided in the cellular environment. In some tissue types, ciliary orientation …