The changing therapeutic landscape of head and neck cancer

JD Cramer, B Burtness, QT Le, RL Ferris - Nature reviews Clinical …, 2019 - nature.com
Head and neck cancers are a heterogeneous collection of malignancies of the upper
aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the …

Targeted therapy for head and neck cancer: signaling pathways and clinical studies

Q Li, Y Tie, A Alu, X Ma, H Shi - Signal transduction and targeted …, 2023 - nature.com
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non …

ML Gillison, AM Trotti, J Harris, A Eisbruch, PM Harari… - The Lancet, 2019 - thelancet.com
Background Patients with human papillomavirus (HPV)-positive oropharyngeal squamous
cell carcinoma have high survival when treated with radiotherapy plus cisplatin. Whether …

Cetuximab, docetaxel, and cisplatin versus platinum, fluorouracil, and cetuximab as first-line treatment in patients with recurrent or metastatic head and neck …

J Guigay, A Aupérin, J Fayette, E Saada-Bouzid… - The Lancet …, 2021 - thelancet.com
Background Results from a phase 2 trial of the TPEx chemotherapy regimen (docetaxel–
platinum–cetuximab) showed promising results, with a median overall survival of 14· 0 …

Guidelines of care for the management of cutaneous squamous cell carcinoma

M Alam, A Armstrong, C Baum, JS Bordeaux… - Journal of the American …, 2018 - Elsevier
Cutaneous squamous cell carcinoma (cSCC) is the second most common form of human
cancer and has an increasing annual incidence. Although most cSCC is cured with office …

Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas

TY Seiwert, Z Zuo, MK Keck, A Khattri… - Clinical cancer …, 2015 - AACR
Purpose: The genetic differences between human papilloma virus (HPV)–positive and–
negative head and neck squamous cell carcinomas (HNSCC) remain largely unknown. To …

[HTML][HTML] Therapeutic approaches for the treatment of head and neck squamous cell carcinoma–An update on clinical trials

B Goel, AK Tiwari, RK Pandey, AP Singh, S Kumar… - Translational …, 2022 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin
cancer with a tobacco consumption and infection with high-risk human papillomavirus (HPV) …

Human papillomavirus and overall survival after progression of oropharyngeal squamous cell carcinoma

C Fakhry, Q Zhang, PF Nguyen-Tan… - Journal of clinical …, 2014 - ascopubs.org
Purpose Risk of cancer progression is reduced for patients with human papillomavirus
(HPV)–positive oropharynx cancer (OPC) relative to HPV-negative OPC, but it is unknown …

Current treatment options for recurrent or metastatic head and neck squamous cell carcinoma

AG Sacco, EE Cohen - Journal of clinical oncology, 2015 - ascopubs.org
This review highlights the evidence-based data to support current best management
practices for patients with recurrent and/or metastatic (R/M) head and neck squamous cell …

[HTML][HTML] The emerging role of immunotherapy in head and neck squamous cell carcinoma (HNSCC): anti-tumor immunity and clinical applications

P Economopoulou, C Perisanidis… - Annals of …, 2016 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinoma (HNSCC) carries a poor prognosis, with low
survival rates for advanced stage tumors and minimal improvement in survival trends …