Colorectal cancer is a heterogeneous disease that develops via stepwise accumulation of
well-characterized genetic and epigenetic alterations. We review the genetic changes …

Colorectal cancer (CRC) is considered a heterogeneous disease, both regarding
pathogenesis and clinical behaviour. Four decades ago, the adenoma–carcinoma pathway …

Our understanding of serrated colorectal polyps has increased dramatically over the past
two decades and has led to a modern classification scheme for these lesions. Sessile …

Recent studies have mapped key genetic changes in colorectal cancer (CRC) that impact
important pathways contributing to the multistep models for CRC initiation and development …

Objectives: Sessile serrated polyps (SSPs) are suggested to be the precursors of 15–30% of
all colorectal cancers (CRCs). Therefore, CRC screening modalities should also be …

Colorectal cancers (CRCs) form a heterogenous group classified into epigenetic and
transcriptional subtypes. The basis for the epigenetic subtypes, exemplified by varying …

Constitutional epimutation, which is an aberration in gene expression due to an altered
epigenotype that is widely distributed in normal tissues (albeit frequently mosaic), provides …

BACKGROUND: CpG island methylator phenotype (CIMP) tumors, comprising 20% of
colorectal cancers, are associated with female sex, age, right-sided location, and BRAF …

Colorectal cancer is a major cause of cancer death and approximately 20% arises within
serrated polyps, which are under-recognized and poorly understood. Human serrated …

The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating
V600E mutation occurs in 15% of sporadic colorectal cancer. This is an early event in …