Caspase-2 is the most evolutionarily conserved member of the mammalian caspase family
and has been implicated in both apoptotic and non-apoptotic signaling pathways, including …

Metastatic melanoma is notoriously one of the most difficult cancers to treat. Although many
therapeutic regimens have been tested, very few achieve response rates greater than 25 …

In this study, we investigated the molecular pathways targeted by curcumin during apoptosis
of human melanoma cell lines. We found that curcumin caused cell death in eight melanoma …

Cypermethrin (CYP), a widely used Type II pyrethroid pesticide, is one of the most common
contaminants in the freshwater aquatic system. We studied the effects of CYP exposure on …

Stathmin is a p53-regulated protein known to influence microtubule dynamics. Because
several chemotherapeutic agents used to treat breast cancer alter the dynamic equilibrium …

Advanced malignant melanoma has a poor prognosis since chemotherapy is mostly
ineffective due in part to the intrinsic and/or extrinsic resistance of melanoma cells to …

Porphyromonas gingivalis is periodontal pathogen that is capable of invading gingival
epithelial cells (GECs). Apoptotic responses of primary cultures of GECs to P. gingivalis …

Previous study indicated that azoxystrobin had high acute toxicity to zebrafish, and larval
zebrafish were more sensitive to azoxystrobin than adult zebrafish. The objective of the …

Melanoma is one of the most aggressive cancers affecting humans. Although early
melanomas are curable with surgical excision, metastatic melanomas are associated with …

While advanced melanoma remains one of the most challenging cancers, recent
developments in our understanding of the molecular drivers of this disease have uncovered …