Calibration of ionic and cellular cardiac electrophysiology models
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …
mathematical models of biological systems. This maturity is bringing new challenges as …
Antiarrhythmic mechanisms of beta blocker therapy
E Grandi, CM Ripplinger - Pharmacological research, 2019 - Elsevier
Sympathetic activity plays an important role in modulation of cardiac rhythm. Indeed, while
exerting positive tropic effects in response to physiologic and pathologic stressors, β …
exerting positive tropic effects in response to physiologic and pathologic stressors, β …
Prediction of arrhythmia susceptibility through mathematical modeling and machine learning
At present, the QT interval on the electrocardiographic (ECG) waveform is the most common
metric for assessing an individual's susceptibility to ventricular arrhythmias, with a long QT …
metric for assessing an individual's susceptibility to ventricular arrhythmias, with a long QT …
A heart for diversity: simulating variability in cardiac arrhythmia research
In cardiac electrophysiology, there exist many sources of inter-and intra-personal variability.
These include variability in conditions and environment, and genotypic and molecular …
These include variability in conditions and environment, and genotypic and molecular …
Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types
Quantitative mismatches between human physiology and experimental models can be
problematic for the development of effective therapeutics. When the effects of drugs on …
problematic for the development of effective therapeutics. When the effects of drugs on …
Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI)
The ability to experimentally perturb biological systems has traditionally been limited to static
pre-programmed or operator-controlled protocols. In contrast, real-time control allows …
pre-programmed or operator-controlled protocols. In contrast, real-time control allows …
Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology
Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications
in disease modeling, cell therapy, drug screening and personalized medicine …
in disease modeling, cell therapy, drug screening and personalized medicine …
Global optimization of ventricular myocyte model to multi-variable objective improves predictions of drug-induced torsades de pointes
T Krogh-Madsen, AF Jacobson, FA Ortega… - Frontiers in …, 2017 - frontiersin.org
In silico cardiac myocyte models present powerful tools for drug safety testing and for
predicting phenotypical consequences of ion channel mutations, but their accuracy is …
predicting phenotypical consequences of ion channel mutations, but their accuracy is …
Dynamic clamp in electrophysiological studies on stem cell–derived cardiomyocytes—Why and how?
AO Verkerk, R Wilders - Journal of Cardiovascular Pharmacology, 2021 - journals.lww.com
Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) are supposed to be a
good human-based model, with virtually unlimited cell source, for studies on mechanisms …
good human-based model, with virtually unlimited cell source, for studies on mechanisms …
Light-activated dynamic clamp using iPSC-derived cardiomyocytes
B Quach, T Krogh-Madsen, E Entcheva, DJ Christini - Biophysical journal, 2018 - cell.com
Abstract iPSC-derived cardiomyocytes (iPSC-CMs) are a potentially advantageous platform
for drug screening because they provide a renewable source of human cardiomyocytes …
for drug screening because they provide a renewable source of human cardiomyocytes …