Proteins synthesized in the endoplasmic reticulum (ER) are properly folded with the
assistance of ER chaperones. Malfolded proteins are disposed of by ER‐associated protein …

Over the last decade, it has become clear that the accumulation of misfolded proteins
contributes to a number of neurodegenerative, immune, and endocrine pathologies, as well …

Vesicular stomatitis virus (VSV) induces apoptosis by at least two mechanisms. The viral
matrix (M) protein induces apoptosis via the mitochondrial pathway due to the inhibition of …

In 1997, caspase-12 was cloned from a murine L929r2 fibrosarcoma cDNA library. 1 As
depicted in Figure 1a, the caspase-12 gene is located on chromosome 9. The genes for …

At vanishingly low concentrations, factors of the neurotrophin family (NGF, BDNF, NT3 and
NT4/5) can promote neuronal survival or death. Many investigations indicate that the …

Taking advantage of the complete genome sequences of several mammals, we developed a
novel method to detect losses of well-established genes in the human genome through …

The endoplasmic reticulum (ER) is the main cellular organelle involved in protein synthesis,
assembly and secretion. Accumulating evidence shows that across several …

Understanding the mechanism by which sortilin affects LDL cholesterol will increase our
understanding of the regulation of lipoprotein metabolism and hepatic lipoprotein export and …

Introduction Every-other-day fasting (EODF) is a classical intermittent fasting (IF) mode with
neuroprotective effects that promotes motor function recovery after spinal cord injury (SCI) in …

Nerve growth factor (NGF) functions as a ligand for two receptors, the TrkA tyrosine kinase
receptor and the p75 neurotrophin receptor (p75NTR). The Ig-like domains of Trk receptors …