Cancer is the second biggest cause of death worldwide. Despite a number of studies being
conducted, the effective mechanism for treating cancer has not yet been fully understood …

Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Calcium ions generate versatile intracellular signals that control key functions in all types of
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

The universality of calcium as an intracellular messenger depends on its enormous
versatility. Cells have a calcium signalling toolkit with many components that can be mixed …

The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …

ABSTRACT Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like
Ca2+, mitochondria are ubiquitous, versatile, and dynamic players in determining both cell …

This article reviews the involvement of the mitochondrial permeability transition pore in
necrotic and apoptotic cell death. The pore is formed from a complex of the voltage …

We sought to understand the relationship between reactive oxygen species (ROS) and the
mitochondrial permeability transition (MPT) in cardiac myocytes based on the observation of …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …