Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …

Alzheimer´ s disease (AD) stands out as the most common chronic neurodegenerative
disorder. AD is characterized by progressive cognitive decline and memory loss, with …

Reactive astrocytes are associated with neuroinflammation and cognitive decline in diverse
neuropathologies; however, the underlying mechanisms are unclear. We used optogenetic …

The complement system, an effector arm of the innate immune system that plays a critical
role in tissue inflammation, the elimination of pathogens and the clearance of dead cells and …

Vascular and immune dysfunctions are thought to be related to the pathogenesis of
inflammatory bowel disease (IBD), but behind this, the exact mechanism of mucosal …

As an essential component of our innate immune system, the complement system is
responsible for our defense against pathogens. The complement cascade has complex …

Age-related macular degeneration (AMD) can lead to irreversible impairment of visual
function, and the number of patients with AMD has been increasing globally. The …

Neuroinflammation is a common feature of diverse nervous system pathologies. In many
instances, it begins at an early stage of the disease, paving the way for further …

Methods We conducted Mendelian randomization (MR) to assess the causal role of
circulating complements in the risk of non-viral liver diseases. A complement-centric protein …

Introduction The antidepressant properties of Hypericum species are known. Hyperibone J,
a principal component found in the flowers of Hypericum bellum, exhibited in vitro anti …