Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …

The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …

Conspectus The development of palladium-catalyzed cross-coupling methods for the
activation of C (sp2)–Br bonds facilitated access to arene-rich molecules, enabling a …

In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …

The late stage functionalization (LSF) of complex biorelevant compounds is a powerful tool
to speed up the identification of structure–activity relationships (SARs) and to optimize …

Hypervalent iodine (III) compounds have found wide application in modern organic
chemistry as environmentally friendly reagents and catalysts. Hypervalent iodine reagents …

Alkyl radicals are key intermediates in organic synthesis. Their classic generation from alkyl
halides has a severe drawback due to the employment of toxic tin hydrides to the point that …

Reactions that involve the addition of carbon‐centered radicals to basic heteroarenes,
followed by formal hydrogen atom loss, have become widely known as Minisci‐type …

The selective and efficient C–H methylation of sp2 and sp3 carbon centres has become a
powerful transformation in the synthetic toolbox. Due to the potential for profound changes to …

A photoelectrochemical method for the C− H alkylation of heteroarenes with
organotrifluoroborates has been developed. The merger of electrocatalysis and photoredox …