COVID-19 and immunomodulation in IBD

MF Neurath - Gut, 2020 - gut.bmj.com
The current coronavirus pandemic is an ongoing global health crisis due to COVID-19,
caused by severe acute respiratory syndrome coronavirus 2. Although COVID-19 leads to …

[PDF][PDF] Targeting the latent reservoir for HIV-1

S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …

ECCO guidelines on the prevention, diagnosis, and management of infections in inflammatory bowel disease

T Kucharzik, P Ellul, T Greuter, JF Rahier… - Journal of Crohn's …, 2021 - academic.oup.com
The introduction and broad use of new immunosuppressive agents, including biologic
agents and JAK inhibitors, have revolutionised treatment of inflammatory bowel disease …

Management of patients with Crohn's disease and ulcerative colitis during the coronavirus disease-2019 pandemic: results of an international meeting

DT Rubin, MT Abreu, V Rai, CA Siegel, V Ahuja… - …, 2020 - gastrojournal.org
The 2020 annual meeting for IOIBD was scheduled to occur in March, but was cancelled
owing to the emergence of COVID-19. Given how this disease might affect patients with IBD …

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

DJ Colby, L Trautmann, S Pinyakorn, L Leyre… - Nature medicine, 2018 - nature.com
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might
minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after …

[HTML][HTML] Sequential LASER ART and CRISPR treatments eliminate HIV-1 in a subset of infected humanized mice

PK Dash, R Kaminski, R Bella, H Su, S Mathews… - Nature …, 2019 - nature.com
Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from
infected cells and tissues. Here, sequential long-acting slow-effective release antiviral …

[HTML][HTML] Functional cure of HIV: the scale of the challenge

MP Davenport, DS Khoury, D Cromer… - Nature Reviews …, 2019 - nature.com
A variety of interventions to induce a functional cure of HIV are being explored, with the aim
being to allow patients to cease antiretroviral therapy (ART) for prolonged periods of time or …

[HTML][HTML] Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

T Bradley, J Pollara, S Santra, N Vandergrift… - Nature …, 2017 - nature.com
Abstract The RV144 Thai trial HIV-1 vaccine of recombinant poxvirus (ALVAC) and
recombinant HIV-1 gp120 subtype B/subtype E (B/E) proteins demonstrated 31% vaccine …

Barriers and strategies to achieve a cure for HIV

MC Pitman, JSY Lau, JH McMahon, SR Lewin - The Lancet HIV, 2018 - thelancet.com
9 years since the report of a cure for HIV after CC chemokine receptor type 5 Δ32 stem cell
transplantation, no other case of HIV cure has been reported, despite much research …

Complex immune correlates of protection in HIV‐1 vaccine efficacy trials

GD Tomaras, SA Plotkin - Immunological reviews, 2017 - Wiley Online Library
Development of an efficacious HIV‐1 vaccine is a major priority for improving human health
worldwide. Vaccine‐mediated protection against human pathogens can be achieved …