Recombinant adeno-associated viruses (AAVs) have emerged as promising gene delivery
vehicles resulting in three US Food and Drug Administration (FDA) and one European …

Immunogenicity has imposed a challenge to efficacy and safety evaluation of adeno-
associated virus (AAV) vector-based gene therapies. Mild to severe adverse events …

Conventional T (Tcon) cells and Foxp3+ T-regulatory (Treg) cells are thought to have
differing metabolic requirements, but little is known of mitochondrial functions within these …

Autoimmune diseases are characterized by an imbalance between regulatory T cells and
effector T-cell subsets, such as Th1 and Th17 cells. Studies have confirmed that natural …

Recombinant adeno-associated virus (AAV) is a promising delivery vehicle for in vivo gene
therapy and has been widely used in> 200 clinical trials globally. There are already several …

Autoimmune hepatitis is an uncommon idiopathic syndrome of immune-mediated
destruction of hepatocytes, typically associated with autoantibodies. The disease etiology is …

Since their discovery, CD4+ CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly
established as a critical cell type for regulating immune homeostasis through a plethora of …

Regulatory T cells (Tregs) play an important role in immunoregulation and have been shown
in animal models to promote transplantation tolerance and curb autoimmunity following their …

Immunosuppression strategies that selectively inhibit effector T cells while preserving and
even enhancing CD4+FOXP3+ regulatory T cells (Treg) permit immune self-regulation and …

Recombinant adeno-associated virus (rAAV) has attracted a significant research focus for
delivering genetic therapies to target cells. This non-enveloped virus has been trialed in …